Short answer
Both are audio interfaces, $649 against $410.
The Apogee Duet 3 reaches 100 dB on 567 of the 567 models here, the Focusrite Scarlett 16i16 (4th Gen) on 553.
| Specification | Apogee Duet 3 | Focusrite Scarlett 16i16 (4th Gen) |
|---|---|---|
| Power into 32Ω | 1.2 W | 55 mW |
| Power into 150Ω | 252 mW | 27 mW |
| Power into 300Ω | 126 mW | 27 mW |
| Power into 600Ω | 63 mW | 14 mW |
| Output impedance | 0.5 Ω | 11 Ω |
| Output noise | not published | not published |
| Price | $649 | $410 |
| Headphones it reaches 100 dB on out of 567 | 567 | 553 |
Not published means the maker leaves it out, so that axis cannot be compared.
| Load | Apogee Duet 3 | Focusrite Scarlett 16i16 (4th Gen) |
|---|---|---|
| 32 Ω | Upper bound | Derived |
| 150 Ω | Upper bound | Derived |
| 300 Ω | Upper bound | Published |
| 600 Ω | Upper bound | Derived |
These two columns are not the same kind of number, and that matters more than the gap between them. Focusrite Scarlett 16i16 (4th Gen) publishes a power rating (at 300 Ω); Apogee Duet 3 publishes no power figure at any load, only a maximum output voltage, so every milliwatt in its column is a ceiling worked out from that voltage.
A ceiling assumes the amplifier holds that voltage into the load, and nothing on Apogee Duet 3’s own sheet says it does. It is the most flattering reading available, and it is used here only because the alternative is a blank. Where the Apogee Duet 3 column looks the stronger of the two, treat the difference as unproven rather than measured. 24 of the 280 sources here are in that position, with no published power rating at any load.
14 headphones reach 100 dB on the Apogee Duet 3 but not on the Focusrite Scarlett 16i16 (4th Gen) — HiFiMAN HE-6se V2, HiFiMAN HE6 Remastered, HiFiMAN Susvara, 11 more.
519 headphones are left alone by the Apogee Duet 3 under the one-eighth rule but coloured by the Focusrite Scarlett 16i16 (4th Gen) (64 Audio Aspire 1, 64 Audio Fourte, 64 Audio Nio, 516 more).
553 of the 567 models here reach 100 dB on both.
Headroom is at a 100 dB SPL peak.
The widest gap on the list is the Shure SE846: Apogee Duet 3 has +39 dB of headroom there against +26 dB. 13 dB is about 21 times the power, which matters for peaks rather than for how loud the music sits.
The hiss columns are empty for Apogee Duet 3 and Focusrite Scarlett 16i16 (4th Gen) because neither maker publishes no output noise figure.
| Headphone | Impedance | Needs | Apogee Duet 3 headroom | Focusrite Scarlett 16i16 (4th Gen) headroom | Apogee Duet 3 hiss | Focusrite Scarlett 16i16 (4th Gen) hiss |
|---|---|---|---|---|---|---|
| Shure SE846 | 9 Ω | 0.04 mW | +39 dB | +26 dB damping | not published | not published |
| Campfire Audio Andromeda 2020 | 9 Ω | 4.0 mW | +19 dB | +6 dB damping | not published | not published |
| Audeze LCD-2 Classic | 70 Ω | 0.79 mW | +28 dB | +16 dB damping | not published | not published |
| Beyerdynamic DT 1990 Pro (250Ω) | 250 Ω | 0.63 mW | +24 dB | +16 dB | not published | not published |
| HiFiMAN HE400se | 25 Ω | 7.9 mW | +21 dB | +7 dB damping | not published | not published |
| Audio-Technica ATH-R70X | 470 Ω | 1.6 mW | +17 dB | +10 dB | not published | not published |
| Sennheiser HD 600 | 300 Ω | 6.6 mW | +13 dB | +6 dB | not published | not published |
| HiFiMAN Susvara | 60 Ω | 50 mW | +11 dB | -1 dB damping | not published | not published |
The Apogee Duet 3 costs $239 more than the Focusrite Scarlett 16i16 (4th Gen). Out of the 567 models here, that difference buys 14 more models driven to 100 dB and 519 more models left alone under the one-eighth rule.
Nothing runs the other way: there is no axis here on which the cheaper of the two does better.
Only published figures count here; blank axes are counted separately.
Each in full: Apogee Duet 3 and Focusrite Scarlett 16i16 (4th Gen).