Short answer
Both are audio interfaces, both at $199.
The PreSonus Quantum ES 2 reaches 100 dB on 561 of the 567 models here, the Focusrite Scarlett 2i2 4th gen on 552.
| Specification | Focusrite Scarlett 2i2 4th gen | PreSonus Quantum ES 2 |
|---|---|---|
| Power into 32Ω | 31 mW | 106 mW |
| Power into 150Ω | 19 mW | 22 mW |
| Power into 300Ω | 22 mW | 11 mW |
| Power into 600Ω | 11 mW | 5.6 mW |
| Output impedance | 50 Ω | not published |
| Output noise | not published | not published |
| Price | $199 | $199 |
| Headphones it reaches 100 dB on out of 567 | 552 | 561 |
Not published means the maker leaves it out, so that axis cannot be compared.
| Load | Focusrite Scarlett 2i2 4th gen | PreSonus Quantum ES 2 |
|---|---|---|
| 32 Ω | Derived | Upper bound |
| 150 Ω | Derived | Upper bound |
| 300 Ω | Published | Upper bound |
| 600 Ω | Derived | Upper bound |
These two columns are not the same kind of number, and that matters more than the gap between them. Focusrite Scarlett 2i2 4th gen publishes a power rating (at 300 Ω); PreSonus Quantum ES 2 publishes no power figure at any load, only a maximum output voltage, so every milliwatt in its column is a ceiling worked out from that voltage.
A ceiling assumes the amplifier holds that voltage into the load, and nothing on PreSonus Quantum ES 2’s own sheet says it does. It is the most flattering reading available, and it is used here only because the alternative is a blank. Where the PreSonus Quantum ES 2 column looks the stronger of the two, treat the difference as unproven rather than measured. 24 of the 280 sources here are in that position, with no published power rating at any load.
9 headphones reach 100 dB on the PreSonus Quantum ES 2 but not on the Focusrite Scarlett 2i2 4th gen — HiFiMAN HE-6se V2, HiFiMAN HE6 Remastered, HiFiMAN Susvara, 6 more.
552 of the 567 models here reach 100 dB on both.
Headroom is at a 100 dB SPL peak.
The widest gap on the list is the Shure SE846: PreSonus Quantum ES 2 has +29 dB of headroom there against +23 dB. 5 dB is about 3.4 times the power, which matters for peaks rather than for how loud the music sits.
The hiss columns are empty for Focusrite Scarlett 2i2 4th gen and PreSonus Quantum ES 2 because neither maker publishes no output noise figure.
| Headphone | Impedance | Needs | Focusrite Scarlett 2i2 4th gen headroom | PreSonus Quantum ES 2 headroom | Focusrite Scarlett 2i2 4th gen hiss | PreSonus Quantum ES 2 hiss |
|---|---|---|---|---|---|---|
| Shure SE846 | 9 Ω | 0.04 mW | +23 dB damping | +29 dB | not published | not published |
| Campfire Audio Andromeda 2020 | 9 Ω | 4.0 mW | +3 dB damping | +9 dB | not published | not published |
| Audeze LCD-2 Classic | 70 Ω | 0.79 mW | +14 dB damping | +18 dB | not published | not published |
| Beyerdynamic DT 1990 Pro (250Ω) | 250 Ω | 0.63 mW | +15 dB damping | +13 dB | not published | not published |
| HiFiMAN HE400se | 25 Ω | 7.9 mW | +5 dB damping | +10 dB | not published | not published |
| Audio-Technica ATH-R70X | 470 Ω | 1.6 mW | +9 dB | +7 dB | not published | not published |
| Sennheiser HD 600 | 300 Ω | 6.6 mW | +5 dB damping | +2 dB | not published | not published |
| HiFiMAN Susvara | 60 Ω | 50 mW | -3 dB damping | +1 dB | not published | not published |
These two cost the same, $199, so price settles nothing. Out of the 567 models here, the PreSonus Quantum ES 2 drives 9 models to 100 dB — and on the other side there is no such advantage at all.
Only published figures count here; blank axes are counted separately.
Each in full: Focusrite Scarlett 2i2 4th gen and PreSonus Quantum ES 2.